D-Glucosamine sulfat
2-Amino-2-deoxy-D-glucose sulfate
CAS: 29031-19-4
Molecular Formula: C6H15NO9S
D-Glucosamine sulfat - Names and Identifiers
| Name | 2-Amino-2-deoxy-D-glucose sulfate |
| Synonyms | DONA Arthro Cevolox Chitosamine Sulfate D-Glucosamine sulfat D-Glucosamine sulfate D-Glucosamine Sulphate D-Glucosamine Sulfate Salt D-glucosamine sulfate NaCl 2-Amino-2-deoxy-D-glucose sulfate 2-amino-2-deoxy-beta-D-glucopyranose D-glucosamine sulfate potassium salt D-GLUCOSAMINE SULFATE SODIUM SALT USP glucosamine sulfate potassium salt, D- 2-amino-2-deoxy-D-glucopyranose sulfate Bis(2-ammonio-2-deoxy-D-glucose) sulfate Bis(2-ammonio-2-deoxy-D-glucose) sulphate D-Glucose, 2-amino-2-deoxy-, sulfate (salt) 2-amino-2-deoxy-beta-D-glucopyranose sulfate Chitosamine Sulfate 2-Amino-2-deoxy-D-glucose XSulfate (2R,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal xsulfate |
| CAS | 29031-19-4 |
| EINECS | 249-379-6 |
| InChI | InChI=1/C6H13NO5.H2O4S/c7-3-5(10)4(9)2(1-8)12-6(3)11;1-5(2,3)4/h2-6,8-11H,1,7H2;(H2,1,2,3,4)/t2-,3-,4-,5-,6?;/m1./s1 |
D-Glucosamine sulfat - Physico-chemical Properties
| Molecular Formula | C6H15NO9S |
| Molar Mass | 277.25 |
| Melting Point | 116 °C |
| Boling Point | 617.6±55.0 °C |
| Flash Point | 225.9°C |
| Solubility | Soluble at 1mg/ml in 1M HCl |
| Vapor Presure | 5.53E-10mmHg at 25°C |
| Appearance | Powder |
| Color | White to Off-white |
| Storage Condition | Inert atmosphere,2-8°C |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. |
| In vitro study | Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity. Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins. Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells. |
D-Glucosamine sulfat - Reference Information
| Introduction | Aminosaccharides are usually used as monosaccharide residues in complex oligosaccharides and polysaccharides. Glucosamine is an amino derivative of monosaccharide glucose. Glucosamine sulfate can significantly relieve the pain of patients with arthritis and rheumatism and improve, prevent, treat and repair connective tissue damage. It also has a certain effect on bone and arthritis inflammation, and it also contributes to acute and chronic inflammation Therefore, it also has a certain effect on heart disease and pneumonia, inhibiting the excessive growth of cancer cells or fibroblasts, and inhibiting and treating cancer and malignant tumors. |
| preparation | 1kg of chitin powder and 1L 1-butyl-3-methylimidazole methyl sulfate, 3L sulfuric acid with a mass concentration of 25% were mixed and stirred at a temperature of 40 ℃ to produce crude mother liquor, and then continuously pumped into a microporous membrane filter using a diaphragm pump to filter to produce sperm mother liquor; the prepared sperm mother liquor and 1-propyl-3-methylimidazolium sulfate ionic liquid are mixed and heated at 75 ℃ for 3 hours to prepare a degradation liquid, wherein the sperm mother liquor and 1-propyl-3-methylimidazolium sulfate ionic liquid The volume ratio is 1:1.25; the activated carbon with chitin mass 0.3% ~ 0.8% is added to the resulting degradation liquid to decolorize, membrane filtration is carried out through a microporous filter or an ultrafine pore filter to retain the filtrate; according to the number of parts by weight, weigh 30 parts of cholic acid, 8 parts of N-methylmaleimide, and 18 parts of dimethylacetamide, 18 parts of ethanol and 13 parts of tetrahydrofuran are placed in a beaker, stirred and mixed and placed in an ice water bath at 0~5 ℃ for heat preservation. After the ice water bath treatment is completed, the filtrate is filtered and the filtrate is collected, rotate and evaporate to 1/2 of the original volume to prepare cholic acid modified liquid; According to the mass ratio of 1:3.5, the filtrate obtained by decolorization and filtration is stirred and mixed with cholic acid modified liquid, and deionized water with the same mass as cholic acid modified liquid is added dropwise. After the dropwise addition is completed, it is placed in a water bath at 52 ℃ for heating for 3 hours, and then rotated and evaporated to dry to obtain bile acylated glucosamine. According to the mass ratio of 1:3.5 the bile acylated glucosamine and deionized water were stirred and mixed, sulfuric acid solution with a mass concentration of 55% was added dropwise at 18 ℃. After the dropwise solution was added to pH 3~4, the dropwise addition was stopped and rotated to dry to obtain D-glucosamine sulfate. The content was determined by HPLC with a yield of 88.9% and a purity of 98.17%. |
| biological activity | Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar, a prominent precursor for the biochemical synthesis of glycosylated proteins and lipids, and is used as a dietary supplement. Glucosamine sulfate is also a natural component of glycosaminoglycans in cartilage matrix and synovial fluid. When used externally, it has pharmacological effects on osteoarthritis cartilage and chondrocytes. |
| use | glucosamine sulfate can be used to prevent and treat various types of osteoarthritis, such as knee joint, hip joint, spine, shoulder, hand, wrist and ankle joints and systemic osteoarthritis. |
Last Update：2024-04-09 20:52:54
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Hefei TNJ Chemical Industry Co.,Ltd.
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Tel: +86-18821248368
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D-Glucosamine sulfat
